COVID-19 and Childhood Cancer Resource Library

Highlights

Global effect of the COVID-19 pandemic on paediatric cancer care: a cross-sectional study – Graetz D, et al. Lancet Child Adolesc Health, 2021.

Clinical characteristics and outcomes of COVID-19 in haematopoietic stem-cell transplantation recipients: an observational cohort study – Sharma A, et al. Lancet Haematol, 2021.

Characterization of COVID‐19 disease in pediatric oncology patients: The New York‐New Jersey regional experienc – Madhusoodhan PP, et al. Pediatr Blood Cancer, 2020.

How Will Patients With Cancer Fare During COVID-19?: Many Unanswered Questions –Virnig BA, et al. JAMA Oncol, 2020.

American Society of Clinical Oncology Road to Recovery Report: Learning From the COVID-19 Experience to Improve Clinical Research and Cancer Care – Pennell NA, et al. J Clin Oncol, 2020.

The effect of clinical decision making for initiation of systemic anticancer treatments in response to the COVID-19 pandemic in England: a retrospective analysis – Clark JJ, et al. Lancet Oncol, 2020.

COVID‐19 infection in febrile neutropenic pediatric hematology oncology patients – Hamdy R, et al. Pediatr Blood Cancer, 2020.

COVID-19 Severity and Outcomes in Patients With Cancer: A Matched Cohort Study – Brar G, et al. J Clin Oncol, 2020. 

SARS-CoV-2 Testing in Patients With Cancer Treated at a Tertiary Care Hospital During the COVID-19 Pandemic – Berghoff AS, et al. JCO Clinical Oncol, 2020. 

Patient management in pediatric oncology during the COVID‐19 pandemic: Report from francophone Africa – Traoré F, et al. Pediatr Blood Cancer, 2020. 

Clinical characteristics and risk factors associated with COVID-19 severity in patients with haematological malignancies in Italy: a retrospective, multicentre, cohort study – Passamonti F, et al. Lancet Haematol, 2020. 

Prevention of COVID‐19 infection in a pediatric oncology ward in Wuhan – Zhang A, et al. Pediatr Blood Cancer, 2020. 

Hematological parameters and peripheral blood morphologic abnormalities in children with COVID‐19 – Yarali N, et al. Pediatr Blood Cancer, 2020. 

Applying Lessons Learned From Low-Resource Settings to Prioritize Cancer Care in a Pandemic – DeBoer RJ, et al. JAMA Oncol, 2020. 

COVID-19 and Cancer Care: Ensuring Safety While Transforming Care Delivery – Mulvey TM & Jacobson JO. J Clin Oncol, 2020. 

COVID‐19 in pediatric cancer patients in a resource‐limited setting: National data from Peru – Montoya J, et al. Pediatr Blood Cancer, 2020.

The impact of the COVID-19 pandemic on cancer deaths due to delays in diagnosis in England, UK: a national, population-based, modelling study – Maringe C, et al. Lancet Oncol, 2020. 

Telemedicine for Cancer Care in the Time of COVID-19 – Royce TJ, et al. JAMA Oncol, 2020. 

Delayed cancer diagnoses and high mortality in children during the COVID‐19 pandemic – Ding Y-Y, et al. Pedaitr Blood Cancer, 2020. 

COVID‐19 in pediatric hematopoietic stem cell transplantation: The experience of Spanish Group of Transplant (GETMON/GETH) – Vicent MG, et al. Pedaitr Blood Cancer, 2020.

Collateral effects of COVID‐19 pandemic in pediatric hematooncology: Fatalities caused by diagnostic delay – Parasole R, et al. Pediatr Blood Cancer, 2020.

The COVID-19 PANDEMIC: A Rapid Global response for Children with Cancer from SIOP, COG, SIOP-E, SIOP-PODC, IPSO, PROS, CCI and St Jude Global – Sullivan M, et al. Pediatr Blood Cancer, 2020.

 

Clinical Characteristics & Outcomes

Clinical presentations and outcomes of children with cancer and COVID-19: A systematic review – Meena JP, et al. Pediatr Blood Cancer, 2021.

SARS‐CoV‐2‐related multisystem inflammatory syndrome in an immunocompromised child with leukemia – Pandrowala A, et al. Pediatr Blood Cancer, 2021.

High mortality of COVID-19 in children with cancer in a single center in Algiers, Algeria – Arous R, et al. Pediatr Blood Cancer, 2021.

COVID-19 infection in children with cancer and stem cell transplant recipients in Turkey: A nationwide study – Kebudi R, te al. Pediatr Blood Cancer, 2021.

Effect of COVID‐19 on anakinra‐induced remission in homozygous STX11 hemophagocytosis lymphohistiocytosis – Vagrecha A, et al. Pediatr Blood Cancer, 2021.

Post‐COVID‐19 severe neutropenia – Bouslama B, et al. Pediatr Blood Cancer, 2020.

Use of Real-World Electronic Health Records to Estimate Risk, Risk Factors, and Disparities for COVID-19 in Patients With Cancer –Desai A, et al. JAMA Oncol, 2020.

How Will Patients With Cancer Fare During COVID-19?: Many Unanswered Questions –Virnig BA, et al. JAMA Oncol, 2020.

COVID-19 in Pediatric Cancer Patients: How Concerned We Should Be? Lessons Learned From a Single Center in Middle East – Ahmad N, et al. J Pediatr Hematol Oncol, 2020. 

COVID19 in children with cancer in low- and middle-income countries: Experience from a cancer center in Chennai, India – Radhakrishnan V, et al. Pediatr Hematol Oncol, 2020. 

Outcomes of patients with hematologic malignancies and COVID-19: A systematic review and meta-analysis of 3377 patients – Vijenthira A, et al. Blood, 2020. 

COVID-19 in Children With Cancers and Post-Hematopoietic Stem Cell Transplantation (HSCT) in Oman – Al Yazidi LS, et al. J Pediatr Hematol Oncol, 2020. 

Severe COVID‐19 infection in a child receiving immunotherapy for cancer – Smith VR, et al. Pediatr Blood Cancer, 2020. 

SARS-CoV-2 Infection During Induction Chemotherapy in a Child With High-risk T-Cell Acute Lymphoblastic Leukemia (T-ALL) – Dantonello TM, et al. J Pediatr Hematol Oncol, 2020. 

Acute chest syndrome in the setting of SARS‐COV‐2 infections—A case series at an urban medical center in the Bronx – Morrone KA, et al. Pediatr Blood Cancer, 2020. 

Are the Anxiety Levels of Pediatric Hematology-Oncology Patients Different From Healthy Peers During the COVID-19 Outbreak? – Cakirgolu S, et al. J Pediatr Hematol Oncol, 2020. 

Respiratory Failure in a Child With Pulmonary Metastatic Osteosarcoma and COVID-19 – Offenbacher R, et al. J Pediatr Hematol Oncol, 2020. 

Lack of transmission of SARS‐CoV‐2 by platelet transfusion from a COVID‐19‐positive donor in a hematopoietic stem cell transplantation patient – Essa MF, et al. Pediatr Blood Cancer, 2020. 

Pediatric patients with benign hematological diseases during the COVID‐19 pandemic – Bayhan T, et al. Pediatr Blood Cancer, 2020. 

SARS‐CoV‐2 infection in a neutropenic pediatric patient with leukemia: Addressing the need for universal guidelines for treatment of SARS‐CoV‐2‐positive, immunocompromised patients – Schied A, et al. Pediatr Blood Cancer, 2020. 

Determinants of COVID-19 disease severity in patients with cancer – Robilotti E, et al. Nature Medicine, 2020.

Pediatric hematology oncology during SARS‐CoV‐2: A brief communication of 28 patients and changes in clinical practice from a single institute in Pakistan – Sajid MI, et al. Pedaitr Blood Cancer, 2020. 

Benign course of SARS‐CoV‐2 infection in a series of pediatric oncology patients – Rossoff J, et al. Pedaitr Blood Cancer, 2020.

SARS‐CoV‐2 infection in two pediatric patients with immune cytopenias: A single institution experience during the pandemic – Rosenzweig JD, et al. Pedaitr Blood Cancer, 2020.

Oncology care in a lower middle‐income country during the COVID‐19 pandemic – Trehan A, et al. Pediatr Blood Cancer, 2020. 

Cancer Patients in SARS-CoV-2 Infection: A Nationwide Analysis in China – Liang W, et al. Lancet Oncol, 2020. 

COVID‐19 infection in children and adolescents with cancer in Madrid – de Rojas T, et al. Pediatr Blood Cancer, 2020.

Effect of Cancer on Clinical Outcomes of Patients With COVID-19: A Meta-Analysis of Patient Data – Giannakoulis VG, et al. JCO Oncol Pract, 2020. 

Poor clinical outcomes for patients with cancer during the COVID-19 pandemic – Tang L, et al. Lancet Oncol, 2020. 

Ethnicity and COVID-19 in children with comorbidities – Harman K, et al. Lancet Child Adolesc Health, 2020.

COVID-19 in Children With Cancer in New York City – Boulad F, et al. JAMA Oncol, 2020. 

COVID‐19 in pediatric oncology from French pediatric oncology and hematology centers: High risk of severe forms? – André N, et al. Pediatr Blood Cancer, 2020.

SARS‐CoV‐2 disease and children under treatment for cancer – Terenziani M, et al. Pediatr Blood Cancer, 2020.

Patients with cancer appear more vulnerable to SARS-COV-2: a multi-center study during the COVID-19 outbreak – Dai M, et al. Cancer Discov, 2020. 

 

Impact on Cancer Care Delivery

Effect of the COVID-19 outbreak on paediatric cancer care in low-income and middle-income countries – Fuentes-Alabi S, et al. Lancet Child Adolesc Health, 2021.

Impact of Strategies for Mitigating Delays and Disruptions in Cancer Care Due to COVID-19: Systematic Review – Pacheco RL, et al. JCO Glob Oncol, 2021.

Prioritizing Delivery of Cancer Treatment During a COVID-19 Lockdown: The Experience of a Clinical Oncology Service in India – Mallick I, et al. JCO Glob Oncol, 2021.

Determinants of COVID-19 Mortality in Patients With Cancer From a Community Oncology Practice in Brazil – Ferrari BL, et al. JCO Glob Oncol, 2021.

Reduction in the Number of Procedures and Hospitalizations and Increase in Cancer Mortality During the COVID-19 Pandemic in Brazil – Fonseca GA, et al. JCO Glob Oncol, 2021.

Five leisure and training activities to help onco‐hematological children to better live hospital isolation during COVID‐19 – Amicucci M, et al. Pediatr Blood Cancer, 2020.

COVID‐19 in pediatric survivors of childhood cancer and hematopoietic cell transplantation from a single center in New York City – Jimenez-Krulander L, et al. Pediatr Blood Cancer, 2020.

Pediatric cancer registration fluctuation in Greece due to COVID‐19 pandemic and changes in health care delivery – JimKourti M, et al. Pediatr Blood Cancer, 2020.

COVID-19 in Children With Cancer: A Single Low-Middle Income Center Experience – Ebeid FS, et al. J Pediatr Hematol Oncol, 2020.

No increase in psychosocial stress of Dutch children with cancer and their caregivers during the first months of the COVID‐19 pandemic –van Gorp M, et al. Pediatr Blood Cancer, 2020.

The effect of clinical decision making for initiation of systemic anticancer treatments in response to the COVID-19 pandemic in England: a retrospective analysis – Clark JJ, et al. Lancet Oncol, 2020.

Association of the COVID-19 Outbreak With Patient Willingness to Enroll in Cancer Clinical Trials – Fleury ME, et al. JAMA Oncol, 2020. 

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study – Glasbey JC, et al. J Clin Oncol, 2020.

Impact of the COVID-19 Pandemic on Cancer Care: A Global Collaborative Study – Jazieh AR, et al. JCO Global Oncol, 2020. 

The COVID‐19 pandemic: Distance‐delivered care for childhood cancer survivors – Burki TK. Pediatr Blood Cancer, 2020. 

Timely pediatric cancer diagnoses: An unexpected casualty of the COVID‐19 surge – O’Neill AF, et al. Pediatr Blood Cancer, 2020. 

Children with cancer during COVID‐19 pandemic: Early experience in Mexico – López‐Aguilar E, et al. Pediatr Blood Cancer, 2020. 

Impact of COVID‐19 on cancer care: A survey from the French Society of Pediatric Oncology (SFCE) – Rouger-Guadichon J, et al. Pediatr Blood Cancer, 2020. 

A collateral effect of the COVID‐19 pandemic: Delayed diagnosis in pediatric solid tumors – Chiaravalli S, et al. Pediatr Blood Cancer, 2020.

Chemotherapy adaptations in a referral tertiary care center in India for ongoing therapy of pediatric patients with solid tumors during COVID19 pandemic and lockdown – Pushpam D, et al. Pediatr Blood Cancer, 2020. 

Delayed presentations of pediatric solid tumors at a tertiary care hospital in the Bronx due to COVID‐19 – Offenbacher R, et al. Pediatr Blood Cancer, 2020. 

Challenges for pediatric hematology oncology in Pakistan during coronavirus pandemic – Ul-Ain R, et al. Pediatr Blood Cancer, 2020. 

The impact of COVID-19 on the cancer care of adolescents and young adults and their well-being: Results from an online survey conducted in the early stages of the pandemic –Košir U, et al. Cancer, 2020.

Summary of COVID‐19 clinical practice adjustments across select institutions – Schultz L, et al. Pediatr Blood Cancer, 2020. 

Impact of Covid19 on a tertiary care pediatric oncology and stem cell transplant unit in Riyadh, Saudi Arabia – Ahmad N, et al. Pediatr Blood Cancer, 2020. 

Telemedicine During the COVID-19 Pandemic: Impact on Care for Rare Cancers – Smrke A, et al. JCO Global Oncol, 2020. 

Children With Cancer in the Time of COVID-19: An 8-week Report From the Six Pediatric Onco-Hematology Centers in Lombardia, Italy – Ferrari A, et al. Pediatr Blood Cancer, 2020. 

COVID‐19 pandemic: A challenge to a child with cancer – Nerli RB, et al. Pediatr Blood Cancer, 2020. 

Delivering pediatric oncology services during a COVID‐19 pandemic in India – Seth R, et al. Pediatr Blood Cancer, 2020.

Statement on the prevention and treatment of COVID‐19 in patients with pediatric cancer in Japan – Iehara T, et al. Pedaitr Blood Cancer, 2020. 

Pediatric Cancer Research: Surviving COVID-19 – Auletta JJ, et al. Pediatr Blood Cancer, 2020. 

Clinical Impact of COVID-19 on Patients With Cancer (CCC19): A Cohort Study – Kuderer NM, et al. Lancet, 2020.

Early impact of the COVID-19 pandemic on paediatric cancer care in Latin America – Vasquez L, et al. Lancet Oncol, 2020. 

Cancer Patient Care during COVID-19 – Harky A, et al. Cancer Cell, 2020. 

SARS-CoV-2 infection anxieties and general population restrictions delay diagnosis and treatment of acute haematological malignancies – Molica M, et al.  Br J Haematol, 2020. 

Managing patients with cancer during the COVID-19 pandemic: frontline experience from Wuhan – Mei H, et al. Lancet Oncol, 2020. 

Fewer cancer diagnoses during the COVID-19 epidemic in the Netherlands – Dinmohamed AG, et al. Lancet Oncol, 2020. 

Impact of the COVID-19 pandemic on the symptomatic diagnosis of cancer: the view from primary care – Jones D, et al. Lancet Oncol, 2020.

COVID-19: impact on cancer workforce and delivery of care – Mayor S. Lancet Oncol, 2020. 

Safety at the Time of the COVID-19 Pandemic: How to Keep our Oncology Patients and Healthcare Workers Safe – Cinar P, et al. J Natl Compr Canc Netw, 2020. 

Oncology Practice During the COVID-19 Pandemic – Schrag D, et al. JAMA, 2020

Lack of protective gear disrupts oncology care – Nelson R. Lancet Oncol, 2020. 

Strategic plan for management of COVID-19 in paediatric haematology and oncology departments – He Y, et al. Lancet Haematol, 2020. 

COVID-19: global consequences for oncology. Lancet Oncol, 2020. 

Challenges posed by COVID-19 to children with cancer – Kotecha RS. Lancet Oncol, 2020. 

 

Recommendations

Retinoblastoma management during the COVID‐19 pandemic: A report by the Global Retinoblastoma Study Group including 194 centers from 94 countries – Fabian ID, et al. Pediatr Blood Cancer, 2020.

A flowchart strategy for children with leukemia during COVID‐19: A nondesignated hospital's experience – Chen H, et al. Pediatr Blood Cancer, 2020. 

COVID‐19 anticoagulation recommendations in children – Loi M, et al. Pediatr Blood Cancer, 2020. 

Providing care for pediatric cancer patients in the COVID‐19 era: Rapid response recommendations from a developing country – Elzembely MM, et al. Pediatr Blood Cancer, 2020. 

Guidance for Children and Young People with Cancer Undergoing Treatment – Children’s Cancer and Leukaemia Group 

Summary of international recommendations in 23 languages for patients with cancer during the COVID-19 pandemic – Mauri D, et al. Lancet Oncol, 2020. 

Practical Considerations for Treating Patients With Cancer in the COVID-19 Pandemic – Segelov E, et al. JCO Oncol Pract, 2020. 

Testing for COVID-19 in Patients With Cancer – Alhalabi O, et al. EclinicalMedicine, 2020

COVID-19 and acute lymphoblastic leukemias of children and adolescents: First recommendations of the Leukemia committee of the French Society for the fight against Cancers and Leukemias in children and adolescents (SFCE) – Baruchel A, et al. Bull Cancer, 2020. 

Lessons after the early management of the COVID-19 outbreak in a pediatric transplant and hemato-oncology center embedded within a COVID-19 dedicated hospital in Lombardia, Italy. Estote parati – Balduzzi A, et al. Bone Marrow Transplant, 2020.  

Ethics and Resource Scarcity: ASCO Recommendations for the Oncology Community During the COVID-19 Pandemic – Marron JM, et al. J Clin Oncol, 2020. 

The official French guidelines to protect patients with cancer against SARS-CoV-2 infection – You B, et al. Lancet Oncol, 2020. 

 

Guidance resources

The Global COVID‐19 Observatory and Resource Center for Childhood Cancer: A response for the pediatric oncology community by SIOP and St. Jude Global – Moreira D, et al. Pediatr Blood Cancer, 2021.

Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19: Molecular Diagnostic Testing – Hanson KE, et al. Clin Infect Dis, 2020.

Guidance regarding COVID‐19 for survivors of childhood, adolescent, and young adult cancer: A statement from the International Late Effects of Childhood Cancer Guideline Harmonization Group – Verburggen LC, et al. Pediatr Blood Cancer, 2020. 

Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19:Serologic Testing – Hanson KE, et al. Clin Infect Dis, 2020. 

COVID–19 Resources for Pediatric Hematologists/Oncologists – American Society of Pediatric Hematology Oncology

COVID-19 Resources and Guidance – International Society of Paediatric Oncology (SIOP)

Care of Individuals with Cancer During COVID-19 – American Society of Clinical Oncology

ASCO Special report: A Guide to Cancer Care Delivery During the COVID-19 Pandemic  – American Society of Clinical Oncology 

Coronavirus (COVID-19) and cancer – Cancer Research UK

COVID-19 Interim Patient Care Guidelines in Hematopoietic Cell Transplant and Cellular Therapy Patients- Association for Stem Cell Transplantation

COVID-19 Rapid guideline: delivery of anticancer treatments – National Institute for Health and Care Excellence

Guidance for Survivors of Childhood, Adolescent or Young Adult Cancer – International Guideline Harmonization Group. Also available in 9 other languages

 

Webinars

Coronavirus in Pediatric Oncology Units with Dr. Miguela Caniza (St. Jude Global Infectious Diseases) - English, Spanish, Portuguese, Russian

 

Radiotherapy

Specific pathways to prevent SARS‐CoV‐2 infection in case of repeated hospital admissions for radiotherapy – Vagelli G, et al. Pediatr Blood Cancer, 2020.

COVID-19 Outbreak and Cancer Patient Management: Viewpoint From Radio-Oncologists – Zhen H, et al. Radiother Oncol

A Rapid Review of Evidence and Recommendations From the SIOPE Radiation Oncology Working Group to Help Mitigate for Reduced Paediatric Radiotherapy Capacity During the COVID-19 Pandemic or Other Crises – Janssens GO, et al. Radiother Oncol, 2020.

COVID-19 Rapid guideline: delivery of radiotherapy – National Institute for Health and Care Excellence

Navigating the Challenges of the COVID-19 Outbreak: Perspectives From the Radiation Oncology Service in Singapore – Tey J, et al. Radiother Oncol, 2020

COVID-19: Global radiation oncology’s targeted response for pandemic preparedness – Simcock, R, et al. Clin Transl Radiat Oncol, 2020

 

Transfusion Medicine

AABB’s Coronavirus Resources - American Association of Blood Banks

 

Surgery and Procedures

Radical change in osteosarcoma surgical plan due to COVID-19 pandemic – Gaston CLL, et al. BMJ Case Rep, 2020. 

Incidence of COVID-19 in Pediatric Surgical Patients Among 3 US Children’s Hospitals – Lin, E, eat al. JAMA Surg, 2020. 

Guidance document for cancer surgery – American College of Surgeons

Cancer Surgery During COVID-19: How We Move Forward – Eng OS, et al. Ann Surg, 2020.

 

Palliative Care

Ensuring Adequate Palliative and Hospice Care During COVID-19 Surges – Abbott J, et al. JAMA, 2020. 

The pervasive relevance of COVID-19 within routine paediatric palliative care consultations during the pandemic: A conversation analytic study – Ekberg K, et al. Palliat Med, 2020. 

A Beacon for Dark Times: Palliative Care Support During the Coronavirus Pandemic – Ankuda CK, et al. NEJM Catal, 2020. 

Palliative Care for Patients With Cancer in the COVID-19 Era – Mehta AK, et al. JAMA Oncol, 2020. 

Coronavirus and Children’s Palliative Care – International Children’s Palliative Care Network

Highlights

A meta-analysis on the role of children in SARS-CoV-2 in household transmission clusters – Zhu Y, et al. Clin Infect Dis, 2020.

SARS-CoV-2 antibody responses in children with MIS-C and mild and severe COVID-19 – Anderson EM, et al. J Pediatric Infect Dis Soc, 2020.

Shedding of Viable SARS-CoV-2 after Immunosuppressive Therapy for Cancer –Aydillo T, et al. N Engl J Med, 2020.

Susceptibility to SARS-CoV-2 Infection Among Children and Adolescents Compared With Adults - A Systematic Review and Meta-analysis – Viner RM, et al. JAMA Pediatr, 2020. 

Frequency of Children vs Adults Carrying Severe Acute Respiratory Syndrome Coronavirus 2 Asymptomatically – Milani GP, et al. JAMA Pediatr, 2020. 

Prevalence of SARS-CoV-2 Infection in Children Without Symptoms of Coronavirus Disease 2019 – Sola AM, et al. JAMA Pediatr, 2020. 

Age-Related Differences in Nasopharyngeal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Levels in Patients With Mild to Moderate Coronavirus Disease 2019 (COVID-19) – Heald-Sargent T, et al. JAMA Pediatr, 2020. 

Rapid Decay of Anti–SARS-CoV-2 Antibodies in Persons with Mild Covid-19 – Ibarraondo FJ, et al. New Engl J Med, 2020. 

Clinical Effectiveness COVID-19 Resources Available to All – UpToDate

Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19) A Review – Wiersinga WJ, et al. JAMA, 2020. 

Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study – Pollán M, et al. Lancet, 2020. 

Diagnostic accuracy of serological tests for covid-19: systematic review and meta-analysis - Bastos ML, et al. BMJ, 2020. 

Multisystem Inflammatory Syndrome in U.S. Children and Adolescents – Feldstein LR, et al. New Engl J Med, 2020. 

Clinical characteristics and risk factors associated with COVID-19 disease severity in patients with cancer in Wuhan, China: a multicentre, retrospective, cohort study – Tian J, et al. Lancet Oncol, 2020. Published online 5/29, 

COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study – Götzinger F, et al. Lancet Child Adolesc Health, 2020.

Epidemiology, Clinical Features, and Disease Severity in Patients with Coronavirus Disease 2019 (COVID-19) in a Children’s Hospital in New York City, New York – Zachariah P, et al. JAMA Pediatr, 2020

Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study – Toubiana J, et al. BMJ, 2020. 

Clinical Effectiveness COVID-19 Resources Available to All – UpToDate

Maintaining essential health services: operational guidance for the COVID-19 context – World Health Organization

Standard Operating Procedure for Triage of Suspected COIVD-19 Patients in non-US Healthcare Settings – US Centers for Disease Control and Prevention 

 

COVID in Children

Characteristics and Disease Severity of US Children and Adolescents Diagnosed With COVID-19 – Preston LE, et al. JAMA Netw Open. 2021.

Trends in Geographic and Temporal Distribution of US Children With Multisystem Inflammatory Syndrome During the COVID-19 Pandemic – Belay ED, et al. JAMA Pediatr, 2021.

Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19- Feldstein L, et al. JAMA, 2021.

Factors Associated With Severe SARS-CoV-2 Infection – Ouldali N, et al. Pediatrics, 2021.

Association of Intravenous Immunoglobulins Plus Methylprednisolone vs Immunoglobulins Alone With Course of Fever in Multisystem Inflammatory Syndrome in Children – Ouldali N, et al. JAMA, 2021.

A meta-analysis on the role of children in SARS-CoV-2 in household transmission clusters – Zhu Y, et al. Clin Infect Dis, 2020.

SARS-CoV-2 antibody responses in children with MIS-C and mild and severe COVID-19 – Anderson EM, et al. J Pediatric Infect Dis Soc, 2020.

Changes in Care Delivery for Children With Sickle Cell Anemia During the COVID-19 Pandemic – Noisette ML, et al. J Pediatr Hematol Oncol, 2020.

Immunological assessment of pediatric multisystem inflammatory syndrome related to COVID-19 – Grazioli S, et al. J Pediatr Infect Dis Soc, 2020. 

Building on an Ad Hoc Covid-19 Response to Enhance Community-based Care for Vulnerable Children in Kerala, India – Govindaraj GM, et al. NEJM Catalyst, 2020.

Are children with SARS-CoV-2 infection at high risk for thrombosis? Viscoelastic testing and coagulation profiles in a case series of pediatric patients – Al-Ghafry M, et al. Pediatr Blood Cancer, 2020. 

Clinical and Epidemiologic Analysis of COVID-19 Children Cases in Colombia PEDIACOVID – Bolaños-Almeida CE, et al. Pediatr Infect Dis J, 2020. 

Hematological manifestations of SARS‐CoV‐2 in children – Kosmeri C, et al. Pediatr Blood Cancer, 2020.

Multisystem Inflammatory Syndrome in Children and SARS-CoV-2 Serology – Zeichner SL & Cruz AT. Pediatrics, 2020. 

Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C) – Goss MB, et al. Cell, 2020. 

Gastrointestinal Symptoms in Severe COVID-19 Children – Giacomet V, et al. Pediatric Infect Dis J, 2020. 

The Natural History of SARS-Cov-2 Related Multisystem Inflammatory Syndrome in Children (MIS-C): A Systematic Review – Aronoff SC, et al. J Pediatric Infect Dis Soc, 2020.

Multicenter interim guidance on use of antivirals for children with COVID-19/SARS-CoV-2  – Chiotos K, et al. J Pediatric Infect Dis Soc, 2020. 

Heavy exposure of children aged 9 to 12 years with SARS-CoV-2 did not lead to infection – Schmidt E & Steinhagen K. J Pediatric Infect Dis Soc, 2020. 

Comparison of Clinical Features of COVID-19 vs Seasonal Influenza A and B in US Children – Song X, et al. JAMA Netw Open, 2020.

Pediatric SARS-CoV-2: Clinical Presentation, Infectivity, and Immune Responses – Yonker LM, et al. J Pediatr, 2020. 

A Pediatric Infectious Disease Perspective of SARS-CoV-2 and COVID-19 in Children – Shane AL, et al. J Pediatric Infect Dis Soc, 2020. 

Multisystem Inflammatory Syndrome Associated With Coronavirus Disease in Children: A Multi-centered Study in Belem, Para, Brazil – de Farias ECF, et al. Pediatr Infect Dis J, 2020. 

Pediatric SARS-CoV-2: Clinical Presentation, Infectivity, and Immune Responses – Yonker LM, et al. J Pediatr, 2020. 

COVID-19 and multisystem inflammatory syndrome in children and adolescents – Jiang L, et al. Lancet Infect Dis, 2020. 

Early Experience of COVID-19 in a US Children' Hospital – Kainth MK, et al. Pediatrics, 2020. 

Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a multicenter observational study – Davies P, et al. Lancet Child Adolesc Health, 2020. 

Neurologic and Radiographic Findings Associated With COVID-19 Infection in Children – Abdel-Mannan O, et al. JAMA Neurol, 2020.

A Case Series of the 2019 Novel Coronavirus (SARS-CoV-2) in 3 Febrile Infants in New York – Feld L, et al. Pediatrics, 2020. 

Multisystem Inflammatory Syndrome in Children in New York State – Dufort EM, et al. New Engl J Med, 2020.

The clinical course of SARS-CoV-2 positive neonates – Bernardo G, et al. Journal of Perinatology, 2020. 

Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study – Stringhini S, et al. Lancet, 2020.

Renal dysfunction in hospitalised children with COVID-19 – Stewart DJ, et al. Lancet Child Adolesc Health, 2020.

Epidemiological Features and Viral Shedding in Children With SARS-CoV-2 Infection – Hua C-Z, et al. J Med Virol, 2020.

Pediatric inflammatory syndrome temporally related to covid-19 – Son MB. BMJ, 2020. 

Coinfection and Other Clinical Characteristics of COVID-19 in Children – Wu Q, et al. Pediatrics, 2020.

Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2 – Whittaker E, et al. JAMA, 2020.

SARS-CoV-2–Related Inflammatory Multisystem Syndrome in Children Different or Shared Etiology and Pathophysiology as Kawasaki Disease? – McCrindle BW, et al. JAMA, 2020. 

Multisystem Inflammatory Syndrome Related to COVID-19 in Previously Healthy Children and Adolescents in New York City – Cheung EW, et al. JAMA, 2020.

Characteristics and Outcomes of Children With Coronavirus Disease 2019 (COVID-19) Infection Admitted to US and Canadian Pediatric Intensive Care Units – Shekerdemian LS, et al. JAMA Pediatr, 2020.

Clinical Characteristics and Outcomes of Hospitalized and Critically Ill Children and Adolescents With Coronavirus Disease 2019 (COVID-19) at a Tertiary Care Medical Center in New York City – Chao JY, et al. J Pediatr, 2020.  

Interim Guidance for Basic and Advanced Life Support in Children and Neonates With Suspected or Confirmed COVID-19 – Tojian A, et al. 

Children with Covid-19 in Pediatric Emergency Departments in Italy – Parri N, et al. New Engl J Med, 2020. 

Epidemiology of COVID-19 Among Children in China – Dong Y, et al. Pediatrics, 2020. 

Coronavirus Disease 2019 and Children: What Pediatric Health Care Clinicians Need to Know – Rasmussen SA, et al. JAMA Pediatr, 2020. 

Systematic review of COVID‐19 in children shows milder cases and a better prognosis than adults – Ludvigsson. Acta Paediatr, 2020 

SARS-CoV-2 Infection in Children – Lu X, et al. N Engl J Med, 2020. 

 

General Clinical

Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B.1.1.7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study – Frampton D, et al. Lancet Infect Dis, 2021.

Diagnostic performance of different sampling approaches for SARS-CoV-2 RT-PCR testing: a systematic review and meta-analysis – Tsang NNY, et al. Lancet Infect Dis, 2021.

S-Gene Target Failure as a Marker of Variant B.1.1.7 Among SARS-CoV-2 Isolates in the Greater Toronto Area, December 2020 to March 2021 – Brown KA, et al. JAMA, 2021.

Performance and operational feasibility of antigen and antibody rapid diagnostic tests for COVID-19 in symptomatic and asymptomatic patients in Cameroon: a clinical, prospective, diagnostic accuracy study – Boum Y, et al. Lancet Infect Dis, 2021.

Effect of Helmet Noninvasive Ventilation vs High-Flow Nasal Oxygen on Days Free of Respiratory Support in Patients With COVID-19 and Moderate to Severe Hypoxemic Respiratory Failure The HENIVOT Randomized Clinical Trial – Grieco DL, et al. JAMA, 2021.

Seroprevalence and humoral immune durability of anti-SARS-CoV-2 antibodies in Wuhan, China: a longitudinal, population-level, cross-sectional study – He A, et al. Lancet 2021.

Major differences in ICU admissions during the first and second COVID-19 wave in Germany – Karagiannidis C, et al. Lancet Respir Med, 2021.

Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study – Young BE, et al. Lancet, 2020. 

COVID-19 and China: lessons and the way forward – Lancet, 2020.

Molecular Underpinnings of Severe Coronavirus Disease 2019 – Plenge R, et al. JAMA, 2020.

Neonatal management and outcomes during the COVID-19 pandemic: an observation cohort study – Salvatore CM, et al. Lancet Child Adolesc Health, 2020. 

COVID-19 Response in Lebanon: Current Experience and Challenges in a Low-Resource Setting – Khoury P, et al. JAMA, 2020. 

Case 24-2020: A 44-Year-Old Woman with Chest Pain, Dyspnea, and Shock – Newton-Cheh C, et al. N Engl J Med, 2020. 

Persistent Symptoms in Patients After Acute COVID-19 – Carfì A, et al. JAMA, 2020. 

Neurological associations of COVID-19 – Ellul MA, et al. Lancet Neurol, 2020. 

Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study – Pollán M, et al. Lancet, 2020. 

Endotheliopathy in COVID-19-associated coagulopathy:evidence from a single-centre, cross-sectional study – Goshua G, et al. Lancet Haematol, 2020. 

Genomewide Association Study of Severe Covid-19 with Respiratory Failure – Ellinghau D, et al. N Engl J Med, 2020.

Facing the Monster in Haiti – Rouzier V, et al. New Engl J Med, 2020. 

The impact of COVID-19 and strategies for mitigation and suppression in low- and middle-income countries – Walker PGT, et al. Science, 2020. 

Severe Covid-19 – Berlin DA, et al. N Engl J Med, 2020. 

An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study – Verdoni L, et al. Lancet, 2020. 

SARS-CoV-2 and Viral Sepsis: Observations and Hypotheses – Li H, et al. Lancet, 2020. 

How to Obtain a Nasopharyngeal Swab Specimen – Marty FM, et al. New Engl J Med, 2020. 

Clinical Characteristics and Outcomes of Hospitalized and Critically Ill Children and Adolescents With Coronavirus Disease 2019 (COVID-19) at a Tertiary Care Medical Center in New York City – Chao JY, et al. J Pediatr, 2020.   

Lessons from COVID-19 in children: Key hypotheses to guide preventative and therapeutic strategies – Singh T, et al. Clin. Infect. Dis, 2020. 

 

Virology

Neutralizing Antibodies Against SARS-CoV-2 Variants After Infection and Vaccination – Edara VV, et al. JAMA, 2021.

Virological Characteristics of Hospitalized Children With SARS-CoV-2 Infection – Pinninti SG, et al. Pediatrics, 2021.

Persistence of Severe Acute Respiratory Syndrome Coronavirus 2 in Aerosol Suspensions – Fears AC, et al. Emerg Infect Dis, 2020. 

Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies – Baum A, et al. Science, 2020. 

Human neutralizing antibodies elicited by SARS-CoV-2 infection – Ju B, et al. Nature, 2020. 

A human neutralizing antibody targets the receptor binding site of SARS-CoV-2 – Shi R, et al. Nature, 2020. 

Prolonged Persistence of SARS-CoV-2 RNA in Body Fluids – Sun J, et al. Emerg Inf Dis, 2020. 

Tropism, Replication Competence, and Innate Immune Responses of the Coronavirus SARS-CoV-2 in Human Respiratory Tract and Conjunctiva: An Analysis in Ex-Vivo and In-Vitro Cultures – Hui K, et al. Lancet Respir Med, 2020. 

Persistence of viral RNA in stool samples from patients recovering from covid-19 – Barth R, et al. BMJ, 2020. 

Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1 – Van Doremalen N, et al. N Engl J Med, 2020 

 

Epidemiology

Cytokine Storms in Cancer and COVID-19 – Turnquist C, et al. Cancer Cell, 2020.

Cancer, COVID-19, and Antiviral Immunity: The CAPTURE Study – Au L, et al. Cell, 2020. 

Trained Innate Immunity, Epigenetics, and Covid-19 – Mantovani A, et al. N Engl J Med, 2020. 

Comparing dynamics and determinants of SARS-CoV-2 transmissions among health care workers of adult and pediatric settings in central Paris – Contejean A, et al. Clin Infect Dis, 2020. 

Natural History of Asymptomatic SARS-CoV-2 Infection – Sakurai A, et al. N Engl J Med, 2020. 

Asymptomatic transmission during the COVID-19 pandemic and implications for public health strategies– Huff HV, et al. Clin. Infect. Dis, 2020. 

COVID-19 in Children and the Dynamics of Infection in Families – Posfay-Barbe KM, et al. Pediatrics, 2020.  

Coronavirus Disease 2019 (COVID-19) and Immune-Engaging Cancer Treatment –  Abid MB, et al. JAMA Oncol, 2020. 

The management of coronavirus disease 2019 – Lui J, et al. J Med Virol, 2020.  

Presymptomatic Transmission of SARS-CoV-2 — Singapore, January 23–March 16, 2020 – Wei WE, et al. Morb Mortal Wkly Rep, 2020. 

Fair Allocation of Scarce Medical Resources in the Time of Covid-19 – Emanuel E, et al. N Engl J Med, 2020. 

 

Resources

LitCovid Database

British Medical Journal – Coronavirus related articles (open access)

Journal of the American Medical Association (JAMA) – Coronavirus Disease (COVID-19) (open access)

New England Journal of Medicine (NEJM) – Coronavirus related articles (open access)

The Lancet – Covid-19 Resource Center (open access)

Coronavirus COVID-19 Global Case Map – Johns Hopkins University

Coronavirus Disease (COVID-19) Pandemic – World Health Organization

Situation Reports – World Health Organization

Coronavirus Disease 2019 – US Centers for Disease Control and Prevention

COVID-19 Patient Impact & Hospital Capacity Module Surveillance Resources – US Centers for Disease Control and Prevention National Healthcare Safety Network

COVID-19 – European Centre for Disease Prevention and Control

Guidelines on the Diagnosis of COVID-19 – Infectious Diseases Society of America

Novel Coronavirus 2019 (COVID-19) Resources – Pediatric Infectious Diseases Society

COVID Fact Sheets – Harvard Health Publishing. Also available in 35+ other languages

Critical Updates on COVID-19 – American Academy of Pediatrics

COVID Guidance and Research Database – Pan American Health Organization (PAHO)

SARS-CoV-2 and COVID-19 – Springer Nature

Novel Coronavirus Information Center – Elsevier Updated

 

Frequently Asked Questions

Coronaviruses - World Health Organization

For Healthcare Professionals– US Centers for Disease Control and Prevention

Coronavirus 2019 and Cancer – American Society of Clinical Oncology. Also available in Spanish

Highlights

Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results – WHO Solidarity Trial Consortium, et al. N Engl J Med, 2020.

Convalescent plasma treatment of severe COVID-19: a propensity score-matched control study – Liu STH, et al. Nat Med, 2020 

Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19: The CoDEX Randomized Clinical Trial – Tomazini BM, et al. JAMA, 2020.

Effect of Hydrocortisone on 21-Day Mortality or Respiratory Support Among Critically Ill Patients With COVID-19: A Randomized Clinical Trial – Dequin P-F, et al. JAMA, 2020. 

Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19: A Randomized Clinical Trial – Spinner CD, et al. JAMA, 2020. 

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis – WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group. JAMA, 2020. 

Remdesivir for severe covid-19: a clinical practice guideline – Rochwerg B, et al. BMJ, 2020. 

Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19 – Cavalcanti AB, et al. New Engl J Med, 2020. 

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report – RECOVERY Collaborative Group, et al. N Engl J Med, 2020.

Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19: A Randomized Clinical Trial – Li L, et al. JAMA, 2020. 

Clinical management of COVID-19 – World Health Organization

Audio Interview: New Data on Remdesivir in Covid-19 – Rubin EJ, et al. N Engl J Med, 2020. 

COVID-19 Treatment Guidelines – National Institutes of Health

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial – Wang Y, et al. Lancet, 2020 

Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19. Geleris J, et al. N Engl J Med, 2020

 

General

Interleukin-1 and interleukin-6 inhibition in patients with COVID-19 and hyperinflammation – Salvatierra J, et al. Lancet Rheumatol, 2021.

Remestemcel-L therapy for COVID-19-associated multisystem inflammatory syndrome in children - Ross Eckard A, et al. Pediatrics.

Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19 – Murai I, et al. JAMA, 2021.

Peginterferon lambda for the treatment of outpatients with COVID-19: a phase 2, placebo-controlled randomised trial – Feld J, et al. Lancet Respir Med, 2021.

Interleukin-1 and interleukin-6 inhibition compared with standard management in patients with COVID-19 and hyperinflammation: a cohort study – Cavalli G, et al. Lancet Rheumatol 2021.

Multidisciplinary Guidance Regarding the Use of Immunomodulatory Therapies for Acute COVID-19 in Pediatric Patients – Dulek DE, et al. J Pediatric Infect Dis Soc, 2020.

Guidelines on the Treatment and Management of Patients with COVID-19 - Infectious Diseases Society of America

Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review – Sanders JM, et al. JAMA, 2020.

Registered clinical trials for COVID-19 - National Institutes of Health

Convalescent donor SARS-COV-2-specific cytotoxic T lymphocyte infusion as a possible treatment option for COVID-19 patients with severe disease - has not received enough attention till date – Sieni E, et al. Br J Haematol, 2020

A real-time dashboard of clinical trials for COVID-19 – Thorlund K, et al. Lancet Digit Health, 2020

Randomized Clinical Trials and COVID-19: Managing Expectations – Bauchner H, et al. JAMA, 2020

 

Antivirals

Comparison of Time to Clinical Improvement With vs Without Remdesivir Treatment in Hospitalized Patients With COVID-19 – Garibaldi BT, et al. JAMA Netw Open, 2021.

Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication – Garcia G, et al. Cell Reports, 2021.

Remdesivir for the Treatment of Covid-19 — Final Report – RECOVERY Collaborative Group, et al. N Engl J Med, 2020. 

Remdesivir for 5 or 10 Days in Patients with Severe Covid-19 – Goldman JD, et al. N Engl J Med, 2020. 

Remdesivir for the Treatment of Covid-19 — Preliminary Report – Beigel JH, et al. N Engl J Med, 2020. 

Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial – Hung I.F-N., et al. Lancet, 2020.

Covid-19 — The Search for Effective Therapy – Baden LR, et al. N Engl J Med, 2020. 5/7

Multicenter initial guidance on use of antivirals for children with COVID-19/SARS-CoV-2 – Chiotos K, et al. J Pediatr Infect Dis Soc, 2020

Compassionate Use of Remdesivir for Patients with Severe Covid-19 – Grein J, et al. N Engl J Med, 2020

A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19 – Cao B, et al. N Engl J Med, 2020

 

Other medications

Initial Guidance on Use of Monoclonal Antibody Therapy for Treatment of COVID-19 in Children and Adolescents – Wolf J, et al. J Pediatric Infect Dis Soc, 2021.

Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia – Salama C, et al. New Engl J Med, 2020.

REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19 – Weinreich DM, et al. New Engl J Med, 2020.

An EUA for Bamlanivimab—A Monoclonal Antibody for COVID-19– Young TK, et al. JAMA, 2020.

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19 – Kalil AC, et al. N Engl J Med, 2020.

Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial – Lenze EJ, et al. JAMA, 2020. 

Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial – Self WH, et al. JAMA, 2020. 

SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19 – Chen P, et al. N Engl J  Med, 2020. 

Efficacy of Tocilizumab in Patients Hospitalized with Covid-19 – Stone JH, et al. N Engl J  Med, 2020. 

Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia: A Randomized Clinical Trial – Hermine O, et al. JAMA Intern Med, 2020. 

Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19 – Beigel JH, et al. N Engl J Med, 2020. 10/8

Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-exposure SARS-CoV-2 Prophylaxis Among Health Care Workers – Abella BS, et al. JAMA Intern Med, 2020. 

Effect of Recombinant Human Granulocyte Colony–Stimulating Factor for Patients With Coronavirus Disease 2019 (COVID-19) and Lymphopenia: A Randomized Clinical Trial – Cheng L-l, et al. JAMA Intern Med, 2020.

The RECOVERY Platform – Normand S-L.T., et al. New Engl J Med, 2020. 

Research in the Context of a Pandemic – Lane HC and Fauci AS. N Engl J Med, 2020. 

Retraction and republication: cardiac toxicity of hydroxychloroquine in COVID-19 - Funck-Brentano C, et al. Lancet, 2020.

Retraction—Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis – Mehra m, et al. Lancet, 2020. 

A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19 – Boulware DR, et al. N Engl J Med, 2020 .

Caution against corticosteroid-based COVID-19 treatment – Tang C, et al. Lancet, 2020. 

Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial – Tang W, et al. BMJ, 2020. 

Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data – Mahévas M, et al. BMJ, 2020. 

Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State – Rosenberg ES, et al. JAMA, 2020. 

Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19 – Geleris J, et al. N Engl J Med, 2020. 

Use of Hydroxychloroquine and Chloroquine During the COVID-19 Pandemic: What Every Clinician Should Know – Yazdany J&Kim AHJ, Ann Intern Med, 2020

Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury – Russel CD, et al. Lancet, 2020

 

Plasma and plasma-derived products

Convalescent plasma from people vaccinated after COVID-19 infection – Jabal, KA, et al. Lancet Microbe 2021.

Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19 A Systematic Review and Meta-analysis – Janiaud P, et al. JAMA, 2021.

A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia – Simonovich VA, et al. N Engl J Med, 2020.

Convalescent plasma for patients with severe COVID-19: a matched cohort study – Rogers RS, et al. Clin Infect Dis, 2020. 

Convalescent Plasma for the Treatment of COVID-19: Perspectives of the National Institutes of Health COVID-19 Treatment Guidelines Panel – Pau AK, et al. Ann Intern Med, 2020. 

Convalescent plasma for pediatric patients with SARS‐CoV‐2‐associated acute respiratory distress syndrome – Diorio C, et al. Pediatr Blood Cancer, 2020. 

Treatment of COVID-19 Patients With Convalescent Plasma – Salazar E, et al. Am J Pathol, 2020. 

Convalescent plasma transfusion for the treatment of COVID-19: Systematic review – Rajendran K, et al. J Med Virol, 2020. 

Effect of Convalescent Plasma Therapy on Viral Shedding and Survival in COVID-19 Patients – Zeng Q-L, et al. J Infect Dis, 2020. 

Treatment With Convalescent Plasma for COVID-19 Patients in Wuhan, China – Ye M, et al. J Med Virol, 2020.

Effectiveness of convalescent plasma therapy in severe COVID-19 patients – Duan K, et al. PNAS, 2020.

Convalescent Plasma to Treat COVID-19: Possibilities and Challenges Roback JD & Guarner J. JAMA, 2020..

Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma– Shen C, et al. JAMA, 2020

Safety and immunogenicity of SARS-CoV-2 recombinant protein vaccine formulations in healthy adults: interim results of a randomised, placebo-controlled, phase 1–2, dose-ranging study – Goepfert PA, et al. Lancet Infect Dis, 2021.

Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial – Chappell KJ, et al. Lancet Infect Dis, 2021.

Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination – Scully M, et al. N Engl J Med, 2021

Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial – Emary K, et al. Lancet, 2021.

Antibody Responses after a Single Dose of SARS-CoV-2 mRNA Vaccine – Bradley T, et al. N Engl J Med, 2021.

Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant – Madhi S, et al. N Engl J Med, 2021.

Immunogenicity of the Ad26.COV2.S Vaccine for COVID-19 – Stephenson KE, et al. JAMA, 2021.

Single-dose Oxford–AstraZeneca COVID-19 vaccine followed by a 12-week booster – Hung I, et al. Lancet, 2021.

Delayed Large Local Reactions to mRNA-1273 Vaccine against SARS-CoV-2 – Blumenthal K, et al. N Engl J Med, 2021.

BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting – Dagan N, et al. N Engl J Med, 2021.

Neutralizing Activity of BNT162b2-Elicited Serum —Preliminary Report – Liu Y, et al. N Engl J Med, 2021.

Serum Neutralizing Activity Elicited by mRNA-1273 Vaccine — Preliminary Report – Wu K, et al. N Engl J Med, 2021.

Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia – Logunov D, et al. Lancet, 2021.

Interim Results of a Phase 1–2a Trial of Ad26.COV2.S Covid-19 Vaccine – Sadoff J, et al. N Engl J Med, 2021. 1/13

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine – Baden LR, et al. N Engl J Med, 2020.

Evaluation of Cloth Masks and Modified Procedure Masks as Personal Protective Equipment for the Public During the COVID-19 Pandemic – Clapp PW, et al. JAMA Intern Med, 2020.

A Cluster-Randomized Trial of Hydroxychloroquine for Prevention of Covid-19 – Polack FP, et al. N Engl J Med, 2020.

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine – Polack FP, et al. N Engl J Med, 2020.

Phase 1–2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine – Polack FP, et al. N Engl J Med, 2020.

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK – Voysey M, et al. Lancet, 2020.

Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination – Widge AT, et al. N Engl J Med, 2020.

Facts about COVID-19 Vaccines – US Centers for Disease Control and Prevention, Multiple languages available

Preventing the Spread of SARS-CoV-2 With Masks and Other “Low-tech” Interventions – Lerner AM, et al. JAMA, 2020. 

Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates – Corbett KS, et al. New Engl J Med, 2020. 

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates – Walsh EE, et al. New Engl J Med, 2020. 

Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia – Logunov DY, et al. Lancet, 2020 

Phase 1–2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine – Keech C. JAMA, 2020. 

An Inactivated Virus Candidate Vaccine to Prevent COVID-19 – Mulligan M. JAMA, 2020. 

Effect of an Inactivated Vaccine Against SARS-CoV-2 on Safety and Immunogenicity Outcomes Interim Analysis of 2 Randomized Clinical Trials – Xia S, et al. JAMA, 2020.

Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates – Corbett KS, et al. New Engl J Med, 2020. 

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial – Folegatti PM, et al. Lancet, 2020. 

Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebocontrolled, phase 2 trial – Zhu FC, et al. Lancet, 2020. 

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report– Jackson LA, et al. New Engl J Med, 2020. 

Vaccines, convalescent plasma, and monoclonal antibodies for covid-19 – Sewell H, et al. BMJ, 2020. 

Physical distancing, face masks, and eye protection for prevention of COVID-19 – MacIntyre CR, et al. Lancet, 2020. 

From Easing Lockdowns to Scaling-Up Community-Based COVID-19 Screening, Testing, and Contact Tracing in Africa – Shared Approaches, Innovations, and Challenges to Minimize Morbidity and Mortality – Nachega JB, et al. Clin. Infect. Dis, 2020. 

The starting line for COVID-19 vaccine development – Lee N, et al. Lancet, 2020. 

Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial – Zhu FC, et al. Lancet, 2020. 

DNA vaccine protection against SARS-CoV-2 in rhesus macaques – Yu J, et al. Science, 2020. 

COVID-19 technical guidance: Infection prevention and control – World Health Organization

Cleaning and disinfection of environmental surfaces in the context of COVID-19 – World Health Organization

Guidelines on Infection Prevention in Patients with Suspected or Known COVID-19 – Infectious Diseases Society of America

Infection prevention and control and preparedness for COVID-19 in healthcare settings technical report – European Centre for Disease Prevention and Control

Checklist for hospitals preparing for the reception and care of coronavirus 2019 (COVID-19) patients – European Centre for Disease Prevention and Control

Examining the current intelligence on COVID-19 and infection prevention and control strategies in health settings: A global analysis – Islam MS, et al. Infect Control Hosp Epidemiol, 2020. 

The feasibility of generalized face mask usage during the COVID-19 pandemic: a perspective from Latin America – Soto DM, et al. Infect Control Hosp Epidemiol, 2020. 

Protecting frontline healthcare workers should be the top priority in low-resource health systems: Bangladesh and COVID-19 – Hassan MZ, et al. Infect Control Hosp Epidemiol, 2020. 

How can airborne transmission of COVID-19 indoors be minimised? – Morawska L, et al. Int J Environ Res Public Health, 2020. 

Redistributing working schedules using the infective principle in the response to COVID-19 – Ćurković M, et al. Infect Control Hosp Epidemiol, 2020. 

Inactivation of Severe Acute Respiratory Syndrome Coronavirus 2 by WHO-Recommended Hand Rub Formulations and Alcohols – Kratzel A, et al. Emerg Infect Dis, 2020.

Keeping the Coronavirus from Infecting Health-Care Workers by Atul Gawande

 

Personal Protective Equipment

Filtering Facepiece Respirator (N95 Respirator) Reprocessing A Systematic Review – Schumm M, et al. JAMA, 2021.

COVID-19: Optimize PPE Supply – US Centers for Disease Control and Prevention

Frequency of face touching with and without a mask in pediatric hematology/oncology health care professionals – Lucas TL, et al. Pediatr Blood Cancer, 2020. 

The Physiological Burden of Prolonged PPE Use on Healthcare Workers during Long Shifts – US Centers for Disease Control and Prevention 

COVID-19-associated shortage of alcohol-based hand rubs, face masks, medical gloves and gowns – proposal for a risk-adapted approach to ensure patient and healthcare worker safety – Kampf G, et al. J Hosp Infect, 2020

Universal Masking in Hospitals in the Covid-19 Era. Klompas M, et al. New Engl J Med, 2020

Guidelines for Decontamination and Reuse of Filtering Facepiece Respirators – US Centers for Disease Control and Prevention

Guidelines for Decontamination and Reuse of Filtering Facepiece Respirators – US Centers for Disease Control and Prevention

Addressing COVID-19 Face Mask Shortage: Can face masks be safely disinfected and reused? – Stanford Medicine

Literature

Risk of Severe COVID-19 Among Workers and Their Household Members – Selden TM, et al. JAMA Intern Med, 2020. 

Professional and Psychological Impacts of the COVID-19 Pandemic on Oncology Residents: A National Survey – Hilmi M, et al. JCO Global Oncol, 2020. 

Understanding the Psychological Impact of COVID-19 Pandemic on Patients With Cancer, Their Caregivers, and Health Care Workers in Singapore – Yao Yi Ng K, et al. JCO Global Oncol, 2020 

Addressing the Mental Health Challenges of Cancer Care Workers in LMICs During the Time of the COVID-19 Pandemic – Datta SS, et al. JCO Global Oncol, 2020 

COVID-19 in Healthcare Workers: A Living Systematic Review and Meta-analysis of Prevalence, Risk Factors, Clinical Characteristics, and Outcomes – Çelebi G, et al. Am J Infect Control, 2020.  

Containment of a traceable COVID-19 outbreak among healthcare workers at a hematopoietic stem cell transplantation unit – Buchtele, N, et al. Bone Marrow Transplanation, 2020. 

Containment of COVID-19 cases amongst healthcare workers: the role of surveillance, early detection and outbreak management – Wee LE, et al. Infect Control Hosp Epidemiol, 2020.  

Occurrence, prevention, and management of the psychological effects of emerging virus outbreaks on healthcare workers: rapid review and meta-analysis – Kisely S, et al. BMJ, 2020.

Knowledge, attitude, practice and perceived barriers among healthcare professionals regarding COVID-19: A Cross-sectional survey from Pakistan – Saqlain M, et al. J Hosp Infect, 2020 

COVID-19: Protecting Healthcare Workers is a priority- Chirico F, et al. Infect Control Hosp Epidemiol, 2020

 

Guidance resources

Coronavirus data – Children’s Cancer and Leukaemia Group

Information for Healthcare Professionals about Coronavirus (COVID-19) – US Centers for Disease Control and Prevention

Information for Pediatric Healthcare Professionals – US Centers for Disease Control and Prevention

Criteria for Return to Work for Healthcare Personnel with Confirmed or Suspected COVID-19 (Interim Guidance)  – US Centers for Disease Control and Prevention

 

For Pregnant Healthcare Professionals

Q&A: Breastfeeding and COVID-19 – World Health Organization

Advice for Pregnant Healthcare Workers – Royal College of Obstetricians & Gynecologists (UK)

Information for Healthcare Providers: COVID-19 and Pregnant Women – US Centers for Disease Control and Prevention

 

WHO Resources

The World Health Organization (WHO) has developed a number of resources related to COVID-19, including  online trainings (listed below) in multiple languages as well as the WHO Academy mobile application for health care professionals.

Infection Prevention and Control for novel coronavirus (COVID-19).

Introduction to emerging respiratory viruses, including novel coronavirus.

Clinical Care Severe Acute Respiratory Infection. 

Health and safety briefing for respiratory diseases – ePROTECT.

Severe Acute Respiratory Infection (SARI) Treatment Facility Design.

COVID-19: Operational Planning Guidelines and COVID-19 Partners Platform to support country preparedness and response.

 

Leadership, Self-Care, and Resilience

Stress Management for Health Care Workers: Real Tips on How to Destress – Purdue University Global

Leadership in a crisis: Responding to the coronavirus outbreak and future challenges – McKinsey & Company

Two Principles for Leading Your Organization Through the COVID-19 Crisis – Kellogg School of Management, Northwestern University

Leading in Our Uncertain Times: Be Real — Not a Hero – The Wharton School, University of Pennsylvania

Leadership Communication: Anticipating and Responding to Stressful Events – Center of the Study of Traumatic Stress

Resilience for Healthcare Professionals – World Child Cancer

Physician Burnout, Interrupted – Hartzband P, et al. New Engl J Med, 2020

Tips for taking care of yourself – US Centers for Disease Control and Prevention

Updates on the Coronavirus – National Institute for Mental Illness

Resilience in Stressful Times Webinar – American Academy of Pediatrics

Resources for Healthcare Professionals Coping with the COVID-19 Pandemic – The Schwartz Center

• Pre-recorded Webinar: Leading with Compassion: Supporting Healthcare Workers in a Crisis, April 7, 2020
• Pre-recorded Webinar: Caring for Yourself & Others During the COVID-19 Pandemic: Managing Healthcare Workers’ Stress, March 24, 2020

Managing Healthcare Workers’ Stress Associated with the COVID-19 Virus Outbreak – US Department of Veterans Affairs. Also available in Spanish

Coronavirus Sanity Guide – Ten Percent Happier: Free 6-month subscription to app for healthcare providers

 

Opportunities

Call for Code Global Challenge - COVID-19: Fight the Global Pandemic – Grant opportunity

 

For Nurses

This section outlines resources and articles that have been developed specifically for nurses. Other sections contain important information for nurses as well. For general information about COVID-19, go to the General COVID-19 Information section.  For information specific to children with cancer and COVID-19, go to the COVID-19 and Pediatric Oncology section. For information about PPE use and conservation, go to the Prevention section. Other information for healthcare providers, including self-care and resilience resources is above in the For Healthcare Providers section.

 

Nursing Highlights

Oncology nursing workforce: challenges, solutions, and future strategies – Challinor JM, et al. Lancet Oncol, 2020.

Pediatric Oncology Nursing during COVID-19 Fact Sheet – St. Jude Global. Also available in Spanish, French, Arabic, Russian, and Portuguese. 

Clinical nursing care guidance for management of patient with COVID-19 – Sharma S, et al. J Pak Med Assoc, 2020. 

How should the role of the nurse change in response to Covid-19? – Purba AK. Nursing Times [online]; 2020. 

Covid‐19: Supporting nurses’ psychological and mental health Maben J et al. J Clin Nurs, 2020

 

Nursing Literature

Challenges faced by mothers caring for children with leukaemia during COVID-19 pandemic: A qualitative study – Attout M, et al. J. Pediatr. Nurs, 2021.

Strategies and resources for nurse leaders to use to lead with empathy and prudence so they understand and address sources of anxiety among nurses practising in the era of COVID-19 – Hofmeyer A, et al. J Clin Nurs, 2020 

COVID-19 Pandemic: Preparing to Care for Patients With Cancer From the Perspective of Low- and Middle-Income Countries – Galassi A, et al. Clin J Oncol Nurs, 2020.

Coronavirus disease 2019 pandemic: Nursing challenges faced – Joshi S. Cancer Res Stat Treat [Online Suppl], 2020

Covid‐19: Supporting nurses’ psychological and mental health Maben J et al. J Clin Nurs, 2020

COVID-19- nurses and midwives impact on global security - Eckert M. AJAN, 2020

Coronavirus 101 Holstein B. J Nurs Pract, 2020

Strengthening the Power of Nursing in Combating COVID-19 Zhang, Y. J Nurs Manag, 2020

2020: The Year of the Nurse as Seen Through a Coronavirus Lens -  Gennaro S. J Nurs Scholarsh, 2020

Vital Role of Nursing to Preserve World Health- Quintana-Zaval, MO. SANUS, 2020

Special attention to nurses' protection during the COVID-19 epidemic Huang L, et al. Crit Care, 2020

Life in the pandemic: Some reflections on nursing in the context of COVID-19 Jackson D. J Clin Nurs, 2020

Nursing and the Novel Coronavirus: Risks and Responsibilities in a Global Outbreak Choi K, et al. J Adv Nurs, 2020

 

Guidance Resources

COVID Vaccine Facts for Nurses - American Nurses Association (ANA)

Coronavirus Information for Nurses – American Nurses Association (ANA)

COVID-19 – Association for Pediatric Hematology/Oncology Nursing (APHON)

COVID-19 Discussion Forum – Association for Pediatric Hematology/Oncology Nursing (log-in required)

COVID-19 Information – Royal College of Nursing

Coronavirus (COVID-19) - Oncology Nursing Society

Interim Guidelines on PPE Use – Oncology Nursing Society. Also available in Spanish, Russian

Recommendations for Oncology Staff Assignments During the COVID-19 Pandemic. -Oncology Nursing Society.

ONS Voice Blog posts – Oncology Nursing Society

 

Previously Recorded Webinars

COVID-19 Considerations (For Pediatric Oncology) by Dr. Sheena Mukkada from St. Jude Children’s Research Hospital, presented to the SIOP PODC Nursing Working Group

COVID-19 Webinar Series: A free, on-demand series for all nurses – American Nurses Association (ANA)

Patients and Families

Together, St. Jude Children’s Research Hospital. Resources for patients, families, and survivors (Also available in Spanish, French, and Arabic)

“Learn about the Coronavirus” Coloring Book (Also available in Spanish , French, Arabic)

American Society of Clinical Oncology What People with Cancer Need to Know (Also available in Spanish)

Children’s Cancer and Leukaemia Group Guidance for Children and Young People with Cancer Undergoing Treatment

Children’s Oncology Group 

Information for Parents of Children with Cancer. Also available in Spanish, French

Information for Childhood Cancer Survivors. Also available in Spanish, French

National Cancer Institute:  What People with Cancer Should Know (Also available in Spanish)

Helmet for EMOTions - Psychological Tips for Children and Adolescents' Emotions. Available in 16 languages.

Inter-Agency Standing Committee Reference Group on Mental Health and Psychosocial Support in Emergency Settings. My Hero is You, Storybook for Children on COVID-19 (Also available in 10+ other languages)